Ctrl-X® SNP Genotyping
Ctrl-X® SNP Genotyping kit accurately distinguishes between Homo and
Hetero types even in a small amount of samples.
ApoE DESCRIPTION
Ctrl-X® ApoE Genotyping qPCR Kit can quickly analyze six genetic polymorphisms of ApoE that have been reported to be closely related to the risk of cardiovascular disease and Alzheimer's disease.
Apolipoprotein E (ApoE) gene is located on chromosome 19 and, as a fat transporter, plays a key role in regulating fat metabolism after damage to the central and peripheral nervous system. In particular, ApoE is known to help in the metabolism of cholesterol during nerve recovery in the central nervous system, and in growth and maintenance of myelin and nerve membrane during development or after damage.
Depending on the DNA polymorphisms of codons 112 (Cys/Arg) and 158 (Arg/Cys) of the ApoE gene, it is divided into three alleles: E2, E3, and E4. Based on the combination of three alleles, it is classified into six genotypes: E2/E2, E3/E3, E4/E4, E2/E3, E2/E4, and E3/E4.
ApoE4 protein is known to be an important risk factor for Alzheimer's disease and coronary artery disease and accumulates ß-amyloid, a known causative agent of Alzheimer's disease. While the ApoE2 protein has a preventive effect on Alzheimer's disease, most patients with type III hypercholesterolemia are known to be homozygous for ApoE2. Therefore, the results of confirming polymorphisms in the ApoE gene may be used to determine the risk of Alzheimer's or to analyze the risk of cardiovascular disease.